S-adenosylhomocysteine hydrolase (SAHH)

SAHH

S-adenosylhomocysteine hydrolase (SAHH) is an NAD+ dependent tetrameric enzyme that catalyzes the hydrolysis of S-adenosylhomocysteine to adenosine and homocystein, participates in the methionine, transsulfurization and transmethylation metabolic pathways, regulates the intracellular levels of homocysteine and adenosine, and thus affecting various aspects of biological metabolism. S-adenosylhomocysteine hydrolase regulates the gene expression and cell growth. S-adenosylhomocysteine hydrolase is related to virus infection, parasite growth like Leishmania, and hyperhomocysteinemia such as atherosclerotic vascular disease and thromboembolic disease^[1].

References:

[1]. Turner MA, et al., Structure and function of S-adenosylhomocysteine hydrolase. Cell Biochem Biophys. 2000;33(2):101-25. [Content Brief]

S-adenosylhomocysteine hydrolase (SAHH) Inhibitors (9)

S-adenosylhomocysteine hydrolase (SAHH) Related Products (9):

Cat. No.	Product Name	Effect	Purity	Chemical Structure

HY-10442

3-Deazaneplanocin A	Inhibitor	99.97%
3-Deazaneplanocin A (DZNep) is a potent histone methyltransferase EZH2 inhibitor. 3-Deazaneplanocin A is a potent S-adenosylhomocysteine hydrolase (AHCY) inhibitor. 3-Deazaneplanocin A shows anti-orthopoxvirus activity.

HY-12186

3-Deazaneplanocin A hydrochloride	Inhibitor	99.98%
3-Deazaneplanocin A hydrochloride (DZNep hydrochloride) is a potent histone methyltransferase EZH2 inhibitor. 3-Deazaneplanocin A hydrochlorideis a potent S-adenosylhomocysteine hydrolase (AHCY) inhibitor. 3-Deazaneplanocin A hydrochloride also has anti-orthopoxvirus and anti-variola activities.

HY-W013332

3-Deazaadenosine	Inhibitor	≥99.0%
3-Deazaadenosine is an inhibitor of S-adenosylhomocysteine hydrolase, with a K_i of 3.9 μM; 3-Deazaadenosine has anti-inflammatory, anti-proliferative and anti-HIV activity.

HY-123055

Adenosine dialdehyde	Inhibitor	99.0%
Adenosine dialdehyde, a purine nucleoside analogue, is a potent inhibitor of S-Adenosylhomocysteine hydrolase (SAHH) (K_i=3.3 nM). Adenosine Dialdehyde exhibits potent anti-tumor activity in vivo and can be used for the cancer research.

HY-W013332A

3-Deazaadenosine hydrochloride	Inhibitor	99.59%
3-Deazaadenosine (hydrochloride) is an inhibitor of S-adenosylhomocysteine hydrolase, with a K_i of 3.9 μM; 3-Deazaadenosine has anti-inflammatory, anti-proliferative and anti-HIV activity.

HY-W002968

SAHH-IN-1	Inhibitor
SAHH-IN-1 (Compound 4) is an inhibitor of S-adenosylhomocysteine hydrolase (SAHH), with an IC₅₀ of 814 nM. SAHH-IN-1 can be used for the study of age-related degenerative diseases (such as Alzheimer's disease).

HY-112639

Aristeromycin	Inhibitor	99.10%
Aristeromycin, an adenosine analog, is an antibiotic and a potent S-adenosylhomocysteine hydrolase (AHCY) inhibitor.

HY-123055R

Adenosine dialdehyde (Standard)	Inhibitor
Adenosine dialdehyde (Standard) is the analytical standard of Adenosine dialdehyde. This product is intended for research and analytical applications. Adenosine dialdehyde, a purine nucleoside analogue, is a potent inhibitor of S-Adenosylhomocysteine hydrolase (SAHH) (Ki=3.3 nM). Adenosine Dialdehyde exhibits potent anti-tumor activity in vivo and can be used for the cancer research.

HY-10442R

3-Deazaneplanocin A (Standard)	Inhibitor
3-Deazaneplanocin A (Standard) is the analytical standard of 3-Deazaneplanocin A (HY-10442). This product is intended for research and analytical applications. 3-Deazaneplanocin A (DZNep) is a potent histone methyltransferase EZH2 inhibitor. 3-Deazaneplanocin A is a potent S-adenosylhomocysteine hydrolase (AHCY) inhibitor. 3-Deazaneplanocin A shows anti-orthopoxvirus activity.

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